| | Name | Amtszeit | Diente unter Präsident(en) |
| 1. | Henry Knox | 1789-1794 | George Washington |
| 2. | Timothy Pickering | 1795 | George Washington |
| 3. | James McHenry | 1769-1800 | George Washington John Adams |
| 4. | Samuel Dexter | 1800-1801 | John Adams |
| 5. | Henry Dearborn | 1801-1809 | Thomas Jefferson |
| 6. | William Eustis | 1809-1813 | James Madison |
| 7. | John Armstrong Jr. | 1813-1814 | James Madison |
| 8. | James Monroe | 1814-1815 | James Madison |
| 9. | William Harris Crawford | 1815-1816 | James Madison |
| 10. | John C. Calhoun | 1817-1825 | James Monroe |
| 11. | James Barbour | 1825-1828 | John Quincy Adams |
| 12. | Peter Buell Porter | 1828-1829 | John Quincy Adams |
| 13. | John Henry Eaton | 1829-1831 | Andrew Jackson |
| 14. | Lewis Cass | 1831-1836 | Andrew Jackson |
| 15. | Joel Roberts Poinsett | 1837-1841 | Martin Van Buren |
| 16. | John Bell | 1841 | William Henry Harrison John Tyler |
| 17. | John C. Spencer | 1841-1843 | John Tyler |
| 18. | James Madison Porter | 1843-1844 | John Tyler |
| 19. | William Wilkins | 1844-1845 | John Tyler |
| 20. | William L. Marcy | 1845-1849 | James Polk |
| 21. | George Walker Crawford | 1849-1850 | Zachary Taylor |
| 22. | Charles Magill Conrad | 1850-1853 | Millard Fillmore |
| 23. | Jefferson Davis | 1853-1857 | Franklin Pierce |
| 24. | John Buchanan Floyd | 1857-1860 | James Buchanan |
| 25. | Joseph Holt | 1861 | James Buchanan |
| 26. | Simon Cameron | 1861-1862 | Abraham Lincoln |
| 27. | Edwin M. Stanton | 1862-1868 | Abraham Lincoln Andrew Johnson |
| 28. | John M. Schofield | 1868-1869 | Andrew Johnson |
| 29. | John Aaron Rawlins | 1869 | Ulysses Simpson Grant |
| 30. | William Tecumseh Sherman | 1869 | Ulysses Simpson Grant |
| 31. | William W. Belknap | 1869-1876 | Ulysses Simpson Grant |
| 32. | Alphonso Taft | 1876 | Ulysses Simpson Grant |
| 33. | J. Donald Cameron | 1876-1877 | Ulysses Simpson Grant |
| 34. | George Washington McCrary | 1877-1879 | Rutherford B. Hayes |
| 35. | Alexander Ramsey | 1879-1881 | Rutherford B. Hayes |
| 36. | Robert Todd Lincoln | 1881-1885 | Chester Alan Arthur |
| 37. | William C. Endicott | 1885-1889 | Grover Cleveland |
| 38. | Redfield Proctor | 1889-1891 | Benjamin Harrison |
| 39. | Stephen B. Elkins | 1891-1893 | Benjamin Harrison |
| 40. | Daniel Scott Lamont | 1893-1897 | Grover Cleveland (2. Amtszeit) |
| 41. | Russell A. Alger | 1897-1899 | William McKinley |
| 42. | Elihu Root | 1899-1904 | William McKinley Theodore Roosevelt |
| 43. | William Howard Taft | 1904-1908 | Theodore Roosevelt |
| 44. | Luke Edward Wright | 1908-1909 | Theodore Roosevelt |
| 45. | Jacob M. Dickinson | 1909-1911 | William Howard Taft |
| 46. | Henry L. Stimson | 1911-1913 | William Howard Taft |
| 47. | Lindley M. Garrison | 1913-1916 | Woodrow Wilson |
| 48. | Newton D. Baker | 1916-1921 | Woodrow Wilson |
| 49. | John W. Weeks | 1921-1925 | Warren G. Harding Calvin Coolidge |
| 50. | Dwight F. Davis | 1925-1929 | Calvin Coolidge |
| 51. | James W. Good | 1929 | Herbert Hoover |
| 52. | Patrick J. Hurley | 1929-1933 | Herbert Hoover |
| 53. | George H. Dern | 1933-1936 | Franklin Delano Roosevelt |
| 54. | Harry H. Woodring | 1936-1940 | Franklin Delano Roosevelt |
| 55. | Henry L. Stimson | 1940-1945 | Franklin Delano Roosevelt Harry S. Truman |
| 56. | Robert P. Patterson | 1945-1947 | Harry S. Truman |
| 57. | Kenneth C. Royall | 1947 | Harry S. Truman |
