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Alfried Krupp Graduate School Tumorbiology

21.08.2006 - (idw) Ernst-Moritz-Arndt-Universität Greifswald

Alfried Krupp Wissenschaftskolleg Greifswald
Martin-Luther-Straße 14, 17487 Greifswald

Alfried Krupp Graduate School Tumorbiology

The Alfried-Krupp-Graduiertenkolleg Tumorbiologie/Alfried Krupp Graduate School Tumorbiology started its program in May 2005. Scientific topics are molecular and cell biological aspects of tumor cell resistance, characterisation of RNA and protein expression patterns and molecular analysis of chromosomal translocations to better understand development and progression of malignancies. Results will give a basis to better understand development and progression of malignancies and for new therapeutic stragies. Altogether ten young scientists work in institutions of both the Faculty of Medicine and the Faculty of Natural Sciences of the University of Greifswald. In addition to the laboratory work monthly seminars with invited speakers give young scientists the opportunity to get in contact with experts of the scientific community. In annual meetings the graduates learn to present and discuss their data in the presence of experts in the field.

In the Summer School 2006 two topics are in the focus of interest. In the first part, new developments in cancer therapies will be presented and discussed. Exciting new advancements in immunotherapies as well as the discussion of the usefulness of stem cells will be part of the program. In the second part, innovative methods and their contributions to the improvement of cancer research will be introduced by scientific experts. The lectures will contain new information on cells growing on chips, mouse models and proteasome chips. At the beginning of the Summer School, the doctoral students supported by the Alfried Krupp von Bohlen und Halbach-Stiftung will present their data achieved in the last funding period.

The Alfried-Krupp-Graduiertenkolleg Tumorbiologie/Alfried Krupp Graduate School Tumorbiology is funded by the Alfried Krupp von Bohlen und Halbach-Stiftung, Essen. The Summer School 2006 is funded by the Alfried Krupp von Bohlen und Halbach-Stiftung, Essen, the Department for Experimental Therapy of the University of Greifswald and the Department for Molecular Medicine of the University of Greifswald.

Prof. Dr. Christian Andreas Schmidt
Phone +49 3834 86-6665, Telefax +49 3834 86-6713,


Monday, 18 September 2006

1:15 pm
Inaugural address
Prof. Dr. h. c. Klaus Pinkau PhD DSc, Wissenschaftlicher Direktor Alfried Krupp Wissenschaftskolleg Greifswald

Update of the Graduate School
Prof. Dr. Christian A. Schmidt, Sprecher des Alfried-Krupp-Graduiertenkollegs Tumorbiologie

Progress reports
Panel 1
Chairs: James F. Beck, Markus M. Lerch
1:30 pm - 1:45 pm
Susceptibility of tumor cells for effector mechanisms of the immune system by inhibition of histone deacetylation
Mareike Schmudde
1:45 pm - 2 pm
Regulation of cell-cell-contact proteins as mechanism for invasive epithelial tumor growth and metastasis in pancreatic carcinoma
Olaf Giermann
2 pm - 2:15 pm
The role of cell-cell contact proteins in the tumorigenesis of pancreatic ductal adenocarcinomas
Matthias Sendler
2:15 pm - 2:30 pm
Expression of the transport proteins MRP4, MRP5 and MRP8 as factors for cytostatic-drug resistance in pancreatic carcinomas
Praveen Kumar
2:30 pm - 2:45 pm
Identification of genes located at chromosomal breakpoints
Kathleen Kruse
2:45 pm - 3:15 pm
Coffee break

Progress reports
Panel 2
Chairs: Gottfried Dölken, Reinhard Walther
3:15 pm - 3:30 pm
Progression and transformation of t(14,18)-positive follicular lymphomas
Tobias Berg
3:30 pm - 3:45 pm
Proteomic Identification of differentially expressed proteins in prostate cancer and their functional characterization
Ramesh Ummanni
3:45 pm - 4 pm
Structure and function of the transcription factor BCL11b
Daniela Dalm
4 pm - 4:15 pm
Proteomanalysis after BCL11b-Knockdown in Jurkat T-cells
Narasima Kumar
4:15 pm - 4:30 pm
Identification of factors affecting radiation and cytokine resistance via differential analysis of histondeacetylase-inhibitor-treated childhood brain tumor cell lines
Chithra Devi Palani
4:30 pm - 5:15 pm
Coffee break
5:15 pm
Special lecture
Quo vadis? Probleme der Wissenschaftsorganisation an deutschen Universitäten
Prof Dr. Cornelius Frömmel, Medizinische Fakultät, Georg-August-Universität Göttingen
6:15 pm
Welcome Reception

Tuesday, 19 September 2006

Panel 1:
Cancer new developments in research and therapy
Chairs: Barbara Bröker, Christoph Ritter
8:30 am - 9:15 am
Developing novel immunotherapies for the treatment of human cancer
Prof. Dolores Schendel PhD, Institut für Molekulare Immunologie, München
9:15 am - 10 am
Adult marrow-derived Very Small Embryonic Like (VSEL) stem cells our key to longevity and a passkey to cancerogenesis
Prof. Dr. Mariusz Z. Ratajczak, Stem Cell Biology Program at James Graham Brown
Cancer Center, University of Louisville (Kentucky)
10 am - 10:45 am
Reprogramming and transdifferentiation of the neoplastic B-cell in Hodgkin's lymphoma
Prof. Dr. Bernd Dörken, Medizinische Klinik mit Schwerpunkt Hämatologie
und Onkologie, Charité - Universitätsmedizin Berlin
10:45 am - 11:15 am
Coffee break
11:15 am - 12 pm
Molecular pathogenesis of childhood leukaemia
Prof. Dr. Arndt Borkhardt, Abteilung Pädiatrische Hämatologie und Onkologie/Stammzelltransplantation
Dr. von Haunersches Kinderspital, Klinikum der Ludwig-Maximilians-Universität München
12 pm - 12:30 pm
Analysis of the Breakpoint Cluster Region downstream from BCL11B in T-cell Acute Lymphoblastic Leukemia (T-ALL)
Dr. Stefan Nagel, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ), Braunschweig
12:30 pm - 2:30 pm
Lunch break
Pommersches Landesmuseum (Guided Tour)

Panel 2:
Innovative methodologies
Chairs: Julia Mayerle, Christian A. Schmidt
2:30 pm - 3 pm
High content analyses of neuronal networks multi electrode sensor chips
Prof. Dr. Dieter G. Weiss, Institut für Zellbiologie und Biosystemtechnik, Universität Rostock
3 pm - 3:30 pm
RZPD Microarray Services
Applications on NimbleGen and Affymetrix Arrays
Dr. Anja Kellermann, RZPD Deutsches Ressourcenzentrum für Genomforschung GmbH, Berlin
3:30 pm - 4 pm
PCR + clamping + chips + ras
Olfert Landt, TIB MOLBIOL GmbH, Berlin
4 pm - 4:30 pm

Providing rapid access to custom made genetically modified mouse models
Dr. Holger Kissel, ARTEMIS Pharmaceuticals GmbH, Köln
4:30 pm - 5 pm
Development of a proteasome chip new strategies
Dr. Hartmut Scheel, Miltenyi Biotec GmbH, MacsMolecular-Abteilung, Köln

Ansprechpartner im Alfried Krupp Wissenschaftskolleg Greifswald
Dr. Reinold Schmücker, Wissenschaftlicher Geschäftsführer, Alfried Krupp Wissenschaftskolleg Greifswald
D-17487 Greifswald
Telefon: 03834 86-19001/-19028, Telefax: 03834 86-19005

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